华学文

个人简介

华学文，男，1988年10月生，山东泰安人，博士研究生，副教授，作物学、风景园林专业硕士生导师，聊城大学“光岳英才”、“党员先锋”，聊城市“水城优秀科技工作者”。

2007.09—2011.06，青岛农业大学，化学与药学院，药学系，理学学士；

2011.09—2013.08，南开大学，元素有机化学国家重点实验室，农药学系，硕士研究生（转博），导师：范志金教授；

2013.09—2016.06，南开大学，元素有机化学国家重点实验室，农药学系，博士研究生，导师：李正名院士。

教学工作

  承担本科生的《现代仪器分析方法》、《农药残留分析与农产品安全》、《专业安全教育》、《植保机具》、《线虫学》等课程的教学和实验工作。

研究方向

天然产物与植物病原真菌的相互作用

基于天然产物的活性分子发现及作用机制探索

专利、奖项

1. 华学文, 房洪斌, 刘洋, 陈占芳, 常静, 郭尚敬, 王桂清. 一种含吡啶结构的酰肼类化合物及其制备和应用. CN 202210672674 .0, 2022.06.15.

2. 华学文, 刘汶芮, 刘艺, 薛晨蒙, 郭尚敬, 王桂清. 含喹啉结构的杂环酯类化合物及其制备方法与应用. CN 202110170394.5, 2021.06.11.

3. 华学文, 王桂清, 苏艳艳, 张蕾蕾, 刘汶芮. 基于SDH的酰胺类绿色杀菌剂的开发及作用机制研究. 聊城大学2021年度科学技术成果奖自然科学一等奖.

科研项目

1. 国家自然科学基金青年基金项目，基于天然产物Waltherione F的杀菌先导优化、构效关系及作用机制研究（32001929），2021/01-2023/12，24万元，在研、主持。

2. 山东省自然科学基金博士基金项目，环境友好型杀线虫剂先导化合物的设计、合成及构效关系研究（ZR2017BC053），2017/07-2019/12，8万元，结题、主持。

3. 聊城大学校级课题，新型杀线虫先导化合物的设计合成、生物活性及构效关系研究（318051625），2017/01-2019/12，8万元，结题、主持。

4. 山东省自然科学基金培养基金项目，过表达AtNRG2对氮素利用及植物生长发育调控的研究（ZR2019PC046），2020/01-2022/12，5万元，结题、参与。

5. 国家自然科学基金青年基金项目，含噻嗪结构的新型HPPD抑制类除草剂的设计、合成及构效关系研究（31701827），2018/01-2020/12，24万元，结题、参与。

代表性成果

1.Zhanfang Chen, Hongbin Fang, Xuewen Hua*, et al. Natural alkaloid waltherione F‑derived hydrazide compounds evaluated in an agricultural fungicidal field. J. Agric. Food Chem., 2023, 71, 12333−12345. (中科院一区)

2.Jing Chang, Yang Liu, Xuewen Hua*, et al. A comprehensive investigation of hydrazide and its derived structures in the agricultural fungicidal field. J. Agric. Food Chem., 2023, 71, 8297−8316. (中科院一区)

3.Hongbin Fang, Zhanfang Chen, Xuewen Hua*, et al. Discovery of aryloxy‑, arylthio‑, and arylamino-containing acethydrazides as fungicidal agents. J. Agric. Food Chem., 2023, 71, 920−933. (中科院一区)

4.Huali Luo, Xuewen Hua*, Zhen Fang*, et al. Toward utilization of lignin-derivatized monomers: development of degradable vanillin-based polyurethane materials. ACS Appl. Polym. Mater., 2023, 5, 6061−6068.

5.Junkang Sui, Jiayi Yang, Xuewen Hua*, et al. Effects of a microbial restoration substrate on plant growth and rhizosphere microbial community in a continuous cropping poplar. Microorganisms, 2023, 11, 486.

6.Zhanfang Chen, Xuewen Hua*, Xiaohe Zhu, et al. Synthesis and biological activity of waltherione F-derived diamide derivatives containing 4-quinolone group. J. Heterocyclic Chem., 2023, 60, 27−38.

7.Hongbin Fang, Zhanfang Chen, Xuewen Hua*, et al. Synthesis and biological activity of amide derivatives derived from natural product Waltherione F. Med. Chem. Res., 2022, 31, 485−496.

8.Zhanfang Chen, Hongbin Fang, Xuewen Hua*, et al. Research on crystal structure and fungicidal activity of the amide derivatives based on the natural products sinapic acid and mycophenolic acid. J. Chem-NY, 2021, 2021, 1036199.

9.Xuewen Hua*, Wenrui Liu, Yan Chen, et al. Synthesis, fungicidal activity, and mechanism of action of pyrazole amide and ester derivatives based on natural products L‑serine and waltherione alkaloids. J. Agric. Food Chem., 2021, 69, 11470−11484. (中科院一区)

10.Wenrui Liu, Xuewen Hua*, Sha Zhou, et al. Design, synthesis and biological activity of N-sulfonyl aromatic amide derivatives. Chinese J. Struct. Chem., 2021, 40, 666‒674.

11.Xuewen Hua*, Nannan Liu, Sha Zhou, et al. Design, synthesis, and biological activity of novel aromatic amide derivatives containing sulfide and sulfone substructures. Engineering, 2020, 6, 553‒559. (中科院一区)

12.Xuewen Hua*, Wenrui Liu, Yanyan Su, et al. Studies on the novel pyridine sulfide containing SDH based heterocyclic amide fungicide. Pest Manag. Sci., 2020, 76, 2368‒2378. (中科院一区，高被引论文)

13.Xuewen Hua*, Nannan Liu, Zhijin Fan, et al. Design, synthesis and biological activity screening of novel amide derivatives containing aromatic thioether group. Chin. J. Org. Chem., 2019, 39, 2581‒2588. (优秀论文奖)

14.Xuewen Hua, Wei Wei, Liangliang Zhu, at al. Synthesis and bioactivity evaluation of novel N-pyridylpyrazolemethanamine derivatives. Chem. Res. Chin. Univ., 2018, 34, 744‒750.

15.Xuewen Hua*, Chen Liu, Sha Zhou, et al. Design, synthesis and insecticidal evaluation of novel N-pyridylpyrazolecarboxamide derivatives containing isoxazole, isoxazoline and 1,3,4-thiadiazole rings. Chem. Res. Chin. Univ., 2017, 33, 882‒889.

16.Xuewen Hua, Minggui Chen, Zhengming Li*, et al. Research on controllable degradation of sulfonylurea herbicides. RSC Adv., 2016, 6, 23038‒23047.

17.Xuewen Hua, Shaa Zhou, Zhengming Li*, et al. Controllable effect of structural modification of sulfonylurea herbicides on soil degradation. Chin. J. Chem., 2016, 34, 1135‒1142.

18.Xuewen Hua, Shaa Zhou, Zhengming Li*, et al. Design, synthesis, and herbicidal activity of novel sulfonylureas containing tetrahydrophthalimide substructure. Chem. Res. Chin. Univ., 2016, 32, 396‒401.

19.Xuewen Hua, Wutao Mao, Zhijin Fan*, et al. Design, synthesis, and biological screening of novel anthranilic diamides. J. Heterocyclic Chem., 2016, 53, 865‒875.

20.Xuewen Hua, Wutao Mao, Zhijin Fan*, et al. Novel anthranilic diamide insecticides: design, synthesis, and insecticidal evaluation. Aust. J. Chem., 2014, 67, 1491‒1503.