郭尚敬

姓      名:郭尚敬
      学      历:博士
      职      称:教授
      院系部门:园林园艺系
      专      业:风景园林学
      联系方式: 0635-8239528  18663000607

E-mail: guoshangjing@lcu.edu.cn

 


个人简介

郭尚敬,男,197011月生,山东阳谷人。博士,教授,硕士生导师。1992年本科毕业于山东农业大学,2000年获山东农业大学硕士学位,2005年获山东农业大学博士学位主要从事植物分子生物学、园林植物种质资源开发与应用等方向的研究。先后主持或参与了国家自然科学基金、国家 “863”计划项目以及省部级科研课题16项;在等J Plant PhysiologicalPlant cell reportBiologia Plantarum国内外学术刊物上发表研究论文70余篇。现任山东省高校教育指导委员会委员,山东省植物生理学会、遗传学会常务理事。


教学工作

承担本科生《植物学》、研究生《园林植物研究进展》等课程的教学工作


研究方向

1.作物生理

2.园林植物种质资源开发与应用


科研项目

  1. 科技部863项目子课题-“动物细胞大规模批次流加培养关键技术及产品研发2012AA02A306),2012-2015,负责人
  2. 国家自然基金-低温胁迫下叶绿体小分子量热激蛋白对植物光系统I的保护机制研究(30671242),2007-2009,负责人
  3. 国家自然基金-植物激素脱落酸与周质微管联络的分子基础(C020407)2013-2014,参与
  4. 国家自然基金-番茄ω-3脂肪酸去饱和酶基因表达与功能分析(30471053)2005-2007,参与
  5. 山东优秀中青年科学家科研奖励基金-“γ-氨基丁酸诱导小麦耐盐性的分子机理基础2008BS07008),2008-2010,负责人
  6. 山东省研究生教育创新计划项目-非全日制教育硕士学位论文质量保证体系研究(sdyy11142),2012-2014,负责人
  7. 山东省高等学校教学改革项目-制药工程类专业应用型创新人才“2+2”校研企合作培养模式的探索与实践(2012213),2013-2015,负责人
  8. 山东省自然基金重点项目,LMO1在肝癌发生发展和转移中的作用机制研究,(ZR2013HZ0022013-2016,参与
  9. 山东省自然基金,甜椒小分子量热激蛋白5对生物膜的低温保护机制(ZR2014CM0132014/9-2017/9,参与
  10. 山东省研究生教育联合培养基地项目-聊城大学东阿阿胶研究生联合培养基地,2017-2020,负责人
  11. 山东省农业科技园区提升工程项目-基于优质蛋白加工的小麦大豆增产提效技术研究推广(2019YQ035),2019-2022,负责人
  12. 教育部产学研合作协同育人项目-基于“互联网+”技术的园林专业虚拟仿真教学中心,2018-2019,负责人
  13. 山东省导师能力提升计划项目-“数字工坊”背景下风景园林学专业硕士研究生“二元化培养模式”的探究(SDYY17147),2017-2020,第2
  14. 山东省导师能力提升计划项目-乡村振兴背景下VR技术在风景园林学硕士研究生教学中的应用研究(322081809),2018-2021,第2
  15. 山东省专业学位研究生教学案例库建设项目-《中外园林历史与发展》教学案例库建设2020-2022,负责人
  16. 教育部新农科研究与改革实践项目-基于多学科交叉融合的智慧农业人才培养模式探索与实践(Z2020038),2020-2024

代表性成果

  1. Zheng HX, Yang Z, Wang WQ, Guo SJ, Li ZX, Liu, KC, Sui N. Transcriptome analysis of maize inbred lines differing in drought tolerance provides novel insights into the molecular mechanisms of drought responses in roots.Plant Physiology and Biochemistry, 2020, 149: 11-26
  2. Xuewen Hua*, Wenrui Liu, Yan Chen, Jing Ru, Shangjing Guo*, Xiaobo Yu, Yanhong Cui,* Xinghai Liu, Yucheng Gu, Chenmeng Xue, Yi Liu, Junkang Sui, and Guiqing Wang. Synthesis, Fungicidal Activity, and Mechanism of Action of Pyrazole Amide and Ester Derivatives Based on Natural Products L‑Serine and Waltherione Alkaloids.J. Agric. Food Chem. 2021, 69, 11470−11484
  3. Ji LS, Li P, Su ZH, Li MF, *Guo SJ. Cold-tolerant introgression line construction and low-temperature stress response analysis for bell pepper. Plant Signaling & Behavior. 2020, 15(7), 1773-1797
  4. Song YS,  Li JL, Sui Y, Han GL, Zhang Y, Guo SJ, Sui N*. The sweet sorghum SbWRKY50 is negatively involved in salt response by regulating ion homeostasis. Plant Molecular Biology. 2020, 102: 603–614
  5. Li MF, Ji LS, Jia ZF, Yang XH, Meng QW, *Guo SJ. Constitutive expression of CaHSP22.5 enhances chilling tolerance in transgenic tobacco by promoting the activity of antioxidative enzymes. Functional Plant Biology, 2018, 45(5): 575-585
  6. Zhang HL, Ren XL, Yang WH, Xie Y,Yang J, *Liu GY, Guo SJ. Synthesis and Evaluation of Anti-Cancer Activities of Mono-Carbonyl Curcumin Analogs. Latin_American_Journal_of_Pharmacy, 2018, 37, 5, 958-963
  7. Zhu XD, Sun Y, Chen D, Li JF, Dong X, Wang J, Chen HWWang Y, Zhang FL, Dai JX, Pirraco RP, Guo SJ, Marques AP, Reis RL, *Li W. Mastocarcinoma therapy synergistically promoted by lysosome dependent apoptosis specifically evoked by 5-Fu@nanogel system with passive targeting and pH activatable dual function. J Controlled Release. 2017, 254: 107-118
  8. Liu GY, Sun YZ, Zhou N, DuXM, *Yang J, *Guo SJ. 3,3′-OH curcumin causes apoptosis in HepG2 cells through ROS-mediated pathway. European Journal of Medicinal Chemistry, 2016, 112: 157-163
  9. Li MF, *Guo SJ, Yang XH, Meng QW, Wei XJ. Exogenous gamma-aminobutyric acid increases salt tolerance of wheat by improving photosynthesis and enhancing activities of antioxidant enzymes. Biologia Plantarum, 2016, 60(1): 123-131
  10. Yu F, Li YChen QHe YWang HYYang LGuo SJ, Meng ZHCui JH, Xue M, *Chen XD. Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency. European Journal of Pharmaceutics and Biopharmaceutics, 2016, 103: 136-148
  11. Bu FF, Liu X, Li JJ, Chen SK, Tong X, Ma CS, Mao H, Pan F, Li XY, Chen B, Xu LY, Li EM, Kou G, Han J, Guo SJ, Zhao J, *Guo YJ. TGF-beta 1 induces epigenetic silence of TIP30 to promote tumor metastasis in esophageal carcinoma. Oncotarget, 2015, 6(4):2120-2133,
  12. Song H, Su X, Yang KX, Niu FF, Li J, Song JJ, Chen HW, Li BH, Li W, Qian WZ, Cao XS, Guo SJ, Dai JX, Feng SS, Guo YJ, Yin C, Gao Jie. CD20 Antibody-Conjugated Immunoliposomes for Targeted Chemotherapy of Melanoma Cancer Initiating Cells Journal of Biomedical. Notechnology, 2015, 11(11): 1927-1946
  13. Wang QL, Guo SJ. Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively. Chinese Medical Journal, 2015, 128(12): 1671-1678,
  14. Su X, Song H, Niu FF, Yang KX, Kou G, Wang XH, Chen HW, Li W, Guo SJ, Li​ J, Li​‌ BH, Feng​‌ SS, Jiang JX, Yin C, Gao J. Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. Nanomedicine. 2015, 10(13): 2033-2050
  15. Xia T, Liang SY, Wang HJ, Hu S, Sun YN, Yu XJ, Han J, Li J, Guo SJ, *Dai JX, Lou ZY, Guo YJ. Structural basis for the neutralization and specificity of Staphylococcal enterotoxin B against its MHC Class II binding site. mAbs, 2014, 6(1): 119-129
  16. Li MF, Guo SJ, Xu Y, Meng QW, Li G, *Yang XH. Glycine betaine-mediated potentiation of HSP gene expression involves calcium signaling pathways in tobacco exposed to NaCl stress. Physiologia Plantarum, 2014, 150(1): 63-75
  17. Li XG, Guo F, Meng JJ, Yang S, Guo SJ, Wan SB. Picimbon JF .Energy dissipation in photosystem 2 complexes of peanut leaves subjected to light pulses. Plant Growth Regulation, 2014, 74(2): 131-138, 2014/11
  18. Li MF, Li ZM, Li SF, Guo SJ, Meng QW, Li G, *Yang XH. Genetic Engineering of Glycine Betaine Biosynthesis Reduces Heat-Enhanced Photoinhibition by Enhancing Antioxidative Defense and Alleviating Lipid Peroxidation in Tomato. Plant Molecular Biology Reporter, 2014, 32(1): 42-51
  19. Tong X, Li L, Li X, Heng L, Zhong L, Su X, Rong R, Hu S, Liu W, Jia B, Liu X, Kou G, Han J,Guo SJ, Hu Y, Li C, Tao Q, Guo Y. SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway.  2014, 5(21): 10571-10583.
  20. *Chen F, *Wang M, Zheng Y, Li SJ, Wang HZ, Han DD, Guo SJ. The Effect of Biocontrol Bacteria on Rhizosphere Bacterial Communities Analyzed by Plating and PCR-DGGE. Current Microbiology, 2013, 67(2): 177-182
  21. Xu L, Su HR, Sun GR, Wang Y, Guo SJ,Zhang XR,  Zhang SS, *Xing SC. Fluorescein-labeled “arch-like” DNA probes for electrochemical detection of DNA on gold nanoparticle-modified gold electrodes. Journal of Biotechnology, 2013, 168(4): 388-393
  22. *Li W, Zhang L, Zhang G, Wei HF, Zhao MX, Li HF, Guo SJ, Gao J, Kou G, Li BH, Dai JX,  Wang H, Guo YJ. The Finely Regulating Well-defined Functional Polymeric Nanocarriers for Anti-tumor Immunotherapy. Mini-Reviews in Medicinal Chemistry, 2013, 13(5): 643-652
  23. Li MF, Ji LS, Yang XH, Meng QW, *Guo SJ.The protective mechanisms of CaHSP26 in transgenic tobacco to alleviate photoinhibition of PSII during chilling stress. Plant Cell Reports, 2012, 31: 1969-1979
  24. Zhang YJ, Yang JS,Guo SJ, Meng JJ., Zhang YL, Wan SB, He QW, *Li XG, Over-expression of the Arabidopsis CBF1 gene improves resistance of tomato leaves to low temperature under low irradiance. Plant Biology, 2011, 13(2), 362-367
  25. GuoSJ, Zhou HY,  Zhang XS,  Li XG, Meng  Overexpression of CaHSP26 in transgenic tobacco alleviates photoinhibition of PSII and PSI during chilling stress under low irradiance. J Plant Physiol. 2007, 164 (2): 126-136.

专 利

  1. 郭尚敬, 李素芬, 张付雷, 李妹芳, 冀芦沙. 全人源EGFR ScFv烟草密码子偏好基因序列及获得方法和应用. 2015/10/7, 中国, (中华人民共和国国家知识产权局,  CN201510399864.X. );授权时间:2019118日,授权公告号:CN 104962562 B
  2. 冀芦沙郭尚敬, 彭向前. 一种植物高效表达载体的优化方法. 2013/11/6, 中国, (中华人民共和国国家知识产权局, CN201210140374.4. )
  3. 陈芳, 董惠钧, 陈坤郭尚敬, 韩军, 周莹一种含海藻基质的复合生防菌剂及制备方法和用途, 2015/11/18,  (中华人民共和国国家知识产权局, CN201510390634.7. )

奖 励

  1. 构建协同创新机制培养拔尖人才,聊城大学教学成果奖二等奖,第1位,2012
  2. 基于创新能力培养的研究生英语教学体系改革, 省研究生教育省级教学成果奖二等奖,第3位,200912
  3. 地方综合性大学研究生培养现状调查与改革研究,省研究生教育省级教学成果奖一等奖,第4位,200912
  4. 小分子量热激蛋白与植物PSIPSII的光抑制保护机理(2008Z20180),省高校优秀科研成果奖二等奖,第1位,20091
  5. Exogenous gamma-aminobutyric acid increases salt tolerance of wheat by improving photosynthesis and enhancing activities of antioxidant enzymes,聊城大学优秀科研成果三等奖,第2位,20174
  6. 姜黄素导向的抗癌药物的设计、合成及其活性机制研究,聊城大学优秀科研成果奖二等奖,第3位,20174